Thanksgiving football: Buffalo Bills (6-4) vs. New Orleans Saints (5-5) — 8:20 p.m. ET

The GIST: Although New Orleans Saints QB Jameis Winston is sidelined for the season with a torn ACL, you’ll still want to save room for this primetime matchup.

Bills: After a red-hot 4-1 start to the season, Buffalo has struggled of late, losing two of their last three with both losses coming to mediocre teams. Early MVP candidate QB Josh Allen will need a standout performance to squash the surfacing doubts about his squad.

Saints: Winston went down with a torn ACL then backup QB Taysom Hill suffered a concussion, ceding the starting role to third-string QB Trevor Siemian, who’s 0-3 in his three starts under center. Not great.

• That said, New Orleans will have an elite running game if RBs Alvin Kamara and Mark Ingram are available.

Prediction: With both squads coming off embarrassing losses in Week 11, it’s hard to know which version of each team will show up tonight. But with the uncertainty surrounding the Saints’ injuries, we have to go with the Bills and their top-ranked defense in this one. Just don’t jump through your Thanksgiving table in celebration, Bills Mafia.